Antiplatelets in Secondary Stroke Prevention

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Antiplatelets in Secondary Stroke Prevention

The aim of this review is to provide evidence-based recommendations on the secondary prevention of atherothrombotic ischemic stroke. Antiplatelets are the major therapy for the secondary stroke prevention. The most commonly used antiplatelets agents are aspirin, clopidogrel, and extended-release dipyridamole. A lot of progress had been made in last years regarding aspirin resistance and genotyp...

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Antiplatelets in secondary stroke prevention: should clopidogrel be the first choice?

Antiplatelet therapy has proven efficacy in the secondary prevention of recurrent non-cardioembolic ischaemic stroke. Recent evidence suggests clopidogrel is as effective as combined therapy with aspirin and extended-release dipyridamole for the prevention of recurrent stroke. As cerebrovascular and ischaemic heart disease are closely related, it would be sensible to use a drug shown to prevent...

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Antiplatelets for stroke prevention: implications of the PRoFESS trial.

Indirect comparisons of CAPRIE, ESPS-2, and MATCH trials led many stroke experts to favor the combination of aspirin and extended-release dipyridamole (ASA/ERD) over clopidogrel as the preferred antiplatelet therapy for secondary stroke prevention.1–3 The Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) study, a 2 2 factorial, double-blind, event-driven, active and placebo-c...

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Secondary prevention of stroke.

Stroke has been defined as a rapid onset of focal neurological deficit lasting more than 24 hours, with no apparent cause other than disruption of the blood supply to the brain (World Health Organization, 1989). A transient ischaemic attack (TIA) refers to a similar presentation that resolves within 24 hours (Hankey and Warlow, 1994). Approximately 15% of strokes are haemorrhagic, with the rest...

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Use of antiplatelets. A survey of secondary prevention of ischemic stroke with intracranial hemorrhage history in Chinese patients.

OBJECTIVE To explore whether antiplatelet (AP) agent therapy increased intracranial hemorrhage (ICH) incidence and reduced ischemic stroke recurrence. METHODS A single-center retrospective cohort study involving 256 cases from 336 Chinese in-patients who had ischemic stroke with ICH history in Beijing Chaoyang Hospital, Beijing, China between May 2005 and October 2009 was conducted. Subjects ...

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ژورنال

عنوان ژورنال: Frontiers in Neurology

سال: 2011

ISSN: 1664-2295

DOI: 10.3389/fneur.2011.00036